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Neuroplastic symptoms · Heart, breathing and autonomic

Skipped beats: when the heart is healthy and the alarm will not stop.

A thump, a pause, a flutter in the chest. The cardiologist says it is benign. Your nervous system has not got the message yet.

Karuna LabsUpdated 2026-10-147 min read
The short answer

PACs (premature atrial contractions) and PVCs (premature ventricular contractions) are extra heartbeats that start outside the heart's normal electrical circuit. Nearly everyone has them, and in a structurally healthy heart they are usually harmless, though they are often felt as a skipped or extra beat and can be tied to anxiety. The ATNS Index of Neuroplastic Symptoms says that when these beats occur often enough to worry a person, an evaluation for neuroplastic symptoms can help, alongside a medical evaluation for other causes. Neuroplastic symptoms are real symptoms produced by a sensitized brain and nervous system rather than by disease. Research shows that only a minority of palpitations line up with actual extra beats, and that anxiety and attention to the body strongly shape how much they are felt. An approach exists that addresses this.

This page is about understanding the condition and the role the brain and nervous system can play in it. It is not a diagnosis. Your own clinicians know your case.

What PACs and PVCs are, and why the heart check comes first

Your heart's rhythm is set by its own electrical pacemaker. Sometimes a beat fires early from somewhere else: from the upper chambers (a premature atrial contraction, or PAC) or the lower chambers (a premature ventricular contraction, or PVC). The early beat is followed by a short pause and then a stronger beat, which is the thump or skip people feel. Almost everyone has some of these every day. Most are never noticed.

The first step is always a medical evaluation. A doctor will take a history, do an ECG, and often arrange a wearable monitor to count the extra beats and check for anything more serious. In a structurally normal heart, PACs and PVCs are generally benign. Very frequent PVCs, usually many thousands a day, can occasionally weaken the heart and need treatment, which is exactly why the count matters.

Caffeine, alcohol, poor sleep, dehydration, thyroid problems and some medicines make extra beats more common. So does anxiety, which the ATNS Index of Neuroplastic Symptoms points out directly.

The neuroplastic contribution

The ATNS index says that if PACs or PVCs are happening often enough to be a concern for the patient, an evaluation for neuroplastic symptoms can sometimes be helpful, along with the medical evaluation for other causes.

Neuroplastic symptoms are real symptoms generated by learned pathways in the brain and nervous system, a sensitized alarm system, rather than by ongoing damage or disease in the body. They are not imaginary and they are reversible, because the brain can change. With extra beats, the neuroplastic part is not the beat itself; it is everything the nervous system does with it.

The brain decides which signals from the body reach awareness. A heartbeat is normally filtered out. Once a skipped beat has frightened you, the brain flags the heart as something to watch. Attention turns inward, the threat system switches on, adrenaline rises, and adrenaline makes extra beats more frequent. Each beat confirms the fear, which sharpens the attention.

What the research shows

A study of 214 patients with frequent PVCs looked at how palpitations related to the extra beats recorded on monitoring. About 58 percent reported palpitations, but only about a third of the whole group had palpitations that clearly matched their PVCs. The authors concluded that a direct link between the symptom and the extra beat could be established only in a minority. Patients with symptoms were also far more likely to have anxiety (about 44 percent versus 14 percent of those without symptoms).

A review of interoception, the sense of the body's internal state, in PVCs proposes that heightened perception of heartbeats comes from the brain's inability to turn down the salience of internal signals when attention to the body is not needed. It notes that the feeling of palpitations may arise without any actual rhythm disturbance, with anxiety and somatic disorders as possible causes.

A nonrandomized before-and-after study tested cognitive behavioral therapy for symptom preoccupation in people with PVCs, targeting fear and hypervigilance toward cardiac sensations and avoidance behaviour, using interoceptive exposure (deliberately producing and observing heart sensations). It measured cardiac anxiety as a key outcome. That is the same logic as neuroplastic treatment: change the brain's relationship with the sensation rather than the sensation itself.

Signs the brain may be part of the picture

Try this today

Sit with your heartbeat for two minutes

Once your doctor has confirmed your heart is healthy, sit quietly and place a hand lightly on your chest. Instead of hoping not to feel anything, invite the sensation in. Feel the rhythm. If a skipped beat comes, notice the thump and the pause and say to yourself: that is an early beat, it is harmless, my brain is checking. Describe it in neutral words (bump, flutter, pause). Breathe out slowly. Stay for two minutes even if you feel a wave of unease. Afterwards, note how many beats you felt and how scared you were from 0 to 10. Repeat daily; the fear number usually falls first.

A solution that addresses it

There is an approach that addresses the brain's contribution directly, and it starts after the cardiologist has done their job. Symptom reprocessing begins with education about neuroplastic symptoms, then builds skills: somatic tracking (observing a skipped beat with curiosity rather than dread), reducing the sense of threat around heart sensations, a graded return to exercise and activity you have been avoiding, emotional awareness and expression, and acceptance and commitment skills. It is delivered by trained clinicians and increasingly through digital programs. Understanding that a sensation can be unpleasant without being dangerous, the lesson of hurt versus harm, applies to the chest as much as to the back.

Cindra is a daily AI companion built around these approaches, with daily check-ins, short practices and plain-language lessons for people whose symptoms have a neuroplastic component. It helps you practise calm attention to the body every day. You can join the waitlist.

What to do next

See your doctor and get the evaluation done: history, ECG and a monitor if advised, plus checks of thyroid, electrolytes and medication. Ask two plain questions: is my heart structurally normal, and is my PVC burden in the safe range? If yes to both, that reassurance is the foundation for everything else.

Then ask whether your experience fits a neuroplastic pattern. If it does, start learning how attention and fear amplify body signals, reduce pulse-checking to what your doctor recommends, and begin a daily practice of noticing heart sensations without reacting. Resume activity gradually; exercise is one of the best ways to teach the brain that a fast or irregular beat is safe. Our page on heart palpitations covers related ground.

Seek urgent care for palpitations with fainting, chest pain, severe breathlessness, or a sustained very fast rhythm, and for extra beats that began after a heart attack or in someone with known heart disease.

Questions people ask

Are PVCs and PACs dangerous?

In a structurally normal heart they are usually benign and extremely common. A medical evaluation with an ECG and monitor confirms this and counts the beats, because very frequent PVCs occasionally need treatment. Always get that check done first.

Are skipped beats a neuroplastic symptom?

The extra beat itself is electrical, not neuroplastic. But how much you feel it, the fear it triggers and how often it occurs are shaped by the nervous system. The ATNS Index of Neuroplastic Symptoms says that when the beats worry you, an evaluation for neuroplastic symptoms can help alongside the medical workup.

Can anxiety cause PVCs?

Anxiety raises adrenaline, which makes extra beats more likely, and it increases attention to the heart, which makes them more noticeable. In one study, patients who felt their PVCs were about three times as likely to have anxiety as those who did not. The two feed each other.

References

  1. Assessment of palpitations in patients with frequent premature ventricular contractions. 2024. PMID 39434258
  2. Exploring the Link Between Interoception and Symptom Severity in Premature Ventricular Contractions. PMC11676546
  3. Cognitive Behavioral Therapy for Symptom Preoccupation Among Patients With Premature Ventricular Contractions: Nonrandomized Pretest-Posttest Study. PMC11109856
Source: the definition and neuroplastic-contribution framing on this page summarise, in our own words, the entry “Heart arrhythmia (pacs and pvcs)” in the Index of Neuroplastic Symptoms (2026) published by the Association for the Treatment of Neuroplastic Symptoms (ATNS, neuroplastic.org). The research summary cites the PubMed records listed above.
Cindra

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Cindra is an AI companion from Karuna Labs built around acceptance and commitment therapy and the science of neuroplastic symptoms. It checks in with you each day, helps you notice what your symptoms are pulling you away from, and nudges you back toward the things that matter. Cindra is invite-only while we build it with early members.

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This article is for general education and is not medical advice, and it does not diagnose or treat any condition. Persistent symptoms deserve a proper medical assessment to rule out disease or injury before a neuroplastic explanation is considered. If your symptoms are new, changing, or come with red-flag signs such as fever, unexplained weight loss, numbness or weakness, chest pain, or loss of bladder or bowel control, see a clinician promptly.